| Description |
IMPUTE is a program for estimating ("imputing") unobserved genotypes in SNP association studies. The program is designed to work seamlessly with the output of the genotype calling program CHIAMO and the population genetic simulator HAPGEN, and it produces output that can be analyzed using the program SNPTEST. There are currently three different versions of the IMPUTE software available for download: version 0.5 implements the methodology described in Marchini et al. (2007); version 1 is essentially the same as version 0.5, with a couple of added features; and version 2 implements a major extension that was introduced in Howie et al. (2009) Official Homepage
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| Documentation |
Users Manual
These links explains the command-line argument that can be used to control IMPUTE
Other References
- J. Marchini, B. Howie, S. Myers, G. McVean and P. Donnelly (2007) A new multipoint method for genome-wide association studies via imputation of genotypes. Nature Genetics 39: 906-913 [Free Access PDF] [Supplementary Material] [News and Views Article]
- B. N. Howie, P. Donnelly and J. Marchini (2009) A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genetics 5(6): e1000529 [Open Access Article]
- J. Marchini and B. Howie (2010) Genotype imputation for genome-wide association studies. Nature Reviews Genetics 11: 499-511 [Restricted Access PDF] [Supplementary Material]
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| License Agreement and Citation Format |
License Agreement
License
Citation Format
If you use IMPUTE2 in a published manuscript, please cite Howie et al. (2009, PLoS Genetics).
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| How to Access the Program |
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Availability
| Servers |
Versions |
Paths |
Parallelization Methods |
| Aurora |
2.1.0 |
/apps/Impute/2.1.0 |
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| Using the Program |
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| Additional Notes |
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